A Randomized Feasibility Pilot Trial of Hearing Treatment for Reducing Cognitive Decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study

Jennifer A. Deal; Marilyn S. Albert; Michelle Arnold; Shrikant I. Bangdiwala; Theresa Chisolm; Sonia Davis; Ann Eddins; Nancy W. Glynn; Adele M. Goman; Melissa Minotti; Thomas Mosley; George W. Rebok; Nicholas Reed; Elizabeth Rodgers; Victoria Sanchez; A. Richey Sharrett; Josef Coresh; Frank R. Lin

doi:10.1016/j.trci.2017.06.003

A Randomized Feasibility Pilot Trial of Hearing Treatment for Reducing Cognitive Decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study

Jennifer A. Deal, Marilyn S. Albert, Michelle Arnold, Shrikant I. Bangdiwala, Theresa Chisolm, Sonia Davis, Ann Eddins, Nancy W. Glynn, Adele M. Goman, Melissa Minotti, Thomas Mosley, George W. Rebok, Nicholas Reed, Elizabeth Rodgers, Victoria Sanchez, A. Richey Sharrett, Josef Coresh, Frank R. Lin

University of South Florida

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults.

Methods: A 40-person (aged 70–84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254.

Results: The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study demonstrated feasibility in recruitment, retention, and implementation of interventions with no treatment-related adverse events. A clear efficacy signal of the hearing intervention was observed in perceived hearing handicap (mean of 0.11 to −1.29 standard deviation [SD] units; lower scores better) and memory (mean of −0.10 SD to 0.38 SD).

Discussion: ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL.

Original language	American English
Journal	Alzheimer's & Dementia: Translational Research & Clinical Interventions
Volume	3
DOIs	https://doi.org/10.1016/j.trci.2017.06.003
State	Published - Jan 1 2017

Keywords

Clinical trials
Cognition
Dementia
Epidemiology
Hearing
Longitudinal study
Memory
Presbycusis

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Deal, J. A., Albert, M. S., Arnold, M., Bangdiwala, S. I., Chisolm, T., Davis, S., Eddins, A., Glynn, N. W., Goman, A. M., Minotti, M., Mosley, T., Rebok, G. W., Reed, N., Rodgers, E., Sanchez, V., Sharrett, A. R., Coresh, J., & Lin, F. R. (2017). A Randomized Feasibility Pilot Trial of Hearing Treatment for Reducing Cognitive Decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 3. https://doi.org/10.1016/j.trci.2017.06.003

A Randomized Feasibility Pilot Trial of Hearing Treatment for Reducing Cognitive Decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study. / Deal, Jennifer A.; Albert, Marilyn S.; Arnold, Michelle et al.
In: Alzheimer's & Dementia: Translational Research & Clinical Interventions, Vol. 3, 01.01.2017.

Research output: Contribution to journal › Article › peer-review

Deal, JA, Albert, MS, Arnold, M, Bangdiwala, SI, Chisolm, T, Davis, S, Eddins, A, Glynn, NW, Goman, AM, Minotti, M, Mosley, T, Rebok, GW, Reed, N, Rodgers, E, Sanchez, V, Sharrett, AR, Coresh, J & Lin, FR 2017, 'A Randomized Feasibility Pilot Trial of Hearing Treatment for Reducing Cognitive Decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study', Alzheimer's & Dementia: Translational Research & Clinical Interventions, vol. 3. https://doi.org/10.1016/j.trci.2017.06.003

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title = "A Randomized Feasibility Pilot Trial of Hearing Treatment for Reducing Cognitive Decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study",

abstract = " Introduction: Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults. Methods: A 40-person (aged 70–84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254. Results: The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study demonstrated feasibility in recruitment, retention, and implementation of interventions with no treatment-related adverse events. A clear efficacy signal of the hearing intervention was observed in perceived hearing handicap (mean of 0.11 to −1.29 standard deviation [SD] units; lower scores better) and memory (mean of −0.10 SD to 0.38 SD). Discussion: ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL.",

keywords = "Clinical trials, Cognition, Dementia, Epidemiology, Hearing, Longitudinal study, Memory, Presbycusis",

author = "Deal, {Jennifer A.} and Albert, {Marilyn S.} and Michelle Arnold and Bangdiwala, {Shrikant I.} and Theresa Chisolm and Sonia Davis and Ann Eddins and Glynn, {Nancy W.} and Goman, {Adele M.} and Melissa Minotti and Thomas Mosley and Rebok, {George W.} and Nicholas Reed and Elizabeth Rodgers and Victoria Sanchez and Sharrett, {A. Richey} and Josef Coresh and Lin, {Frank R.}",

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doi = "10.1016/j.trci.2017.06.003",

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T1 - A Randomized Feasibility Pilot Trial of Hearing Treatment for Reducing Cognitive Decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study

AU - Deal, Jennifer A.

AU - Albert, Marilyn S.

AU - Arnold, Michelle

AU - Bangdiwala, Shrikant I.

AU - Chisolm, Theresa

AU - Davis, Sonia

AU - Eddins, Ann

AU - Glynn, Nancy W.

AU - Goman, Adele M.

AU - Minotti, Melissa

AU - Mosley, Thomas

AU - Rebok, George W.

AU - Reed, Nicholas

AU - Rodgers, Elizabeth

AU - Sanchez, Victoria

AU - Sharrett, A. Richey

AU - Coresh, Josef

AU - Lin, Frank R.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Introduction: Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults. Methods: A 40-person (aged 70–84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254. Results: The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study demonstrated feasibility in recruitment, retention, and implementation of interventions with no treatment-related adverse events. A clear efficacy signal of the hearing intervention was observed in perceived hearing handicap (mean of 0.11 to −1.29 standard deviation [SD] units; lower scores better) and memory (mean of −0.10 SD to 0.38 SD). Discussion: ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL.

AB - Introduction: Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults. Methods: A 40-person (aged 70–84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254. Results: The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study demonstrated feasibility in recruitment, retention, and implementation of interventions with no treatment-related adverse events. A clear efficacy signal of the hearing intervention was observed in perceived hearing handicap (mean of 0.11 to −1.29 standard deviation [SD] units; lower scores better) and memory (mean of −0.10 SD to 0.38 SD). Discussion: ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL.

KW - Clinical trials

KW - Cognition

KW - Dementia

KW - Epidemiology

KW - Hearing

KW - Longitudinal study

KW - Memory

KW - Presbycusis

UR - https://digitalcommons.usf.edu/csd_facpub_sm/9

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VL - 3

JO - Alzheimer's & Dementia: Translational Research & Clinical Interventions

JF - Alzheimer's & Dementia: Translational Research & Clinical Interventions

ER -

A Randomized Feasibility Pilot Trial of Hearing Treatment for Reducing Cognitive Decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study

Abstract

Keywords

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