Big Data Analysis of Drug Induced Hypersensitivity and Anaphylaxis Reactions in Clinical Cancer Trials

Christina Eldredge; Arun Singavi; Cesar Lam; Joel Gallagher; Jake Luo

doi:10.1016/j.jaci.2017.12.279

Big Data Analysis of Drug Induced Hypersensitivity and Anaphylaxis Reactions in Clinical Cancer Trials

Christina Eldredge, Arun Singavi, Cesar Lam, Joel Gallagher, Jake Luo

University of South Florida

Research output: Contribution to conference › Presentation

Abstract

The dataset, which included study name, medical condition, intervention, arm titles, and adverse drug reactions, was queried for drug hypersensitivity reactions using the key terms: hypersensitivity, allergic reaction, allergy, anaphylaxis, allergic dermatitis, and drug hypersensitivity. Results Preliminary population analysis of 425 of the 1605 qualifying clinical trials from this dataset revealed 3,013 adverse drug hypersensitivity reactions of 118,159 patients at risk for HSRs (2.5% incidence).

Original language	American English
DOIs	https://doi.org/10.1016/j.jaci.2017.12.279
State	Published - Mar 1 2018
Event	Journal of Allergy and Clinical Immunology - Duration: Mar 1 2018 → …

Conference

Conference	Journal of Allergy and Clinical Immunology
Period	3/1/18 → …

Keywords

Cancer
Clinical trials
Data management
Data processing
Data analysis
Anaphylaxis
Studies
Hypersensitivity

Disciplines

Medicine and Health Sciences

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10.1016/j.jaci.2017.12.279License: CC BY

https://doi.org/10.1016/j.jaci.2017.12.279

Cite this

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title = "Big Data Analysis of Drug Induced Hypersensitivity and Anaphylaxis Reactions in Clinical Cancer Trials",

abstract = " The dataset, which included study name, medical condition, intervention, arm titles, and adverse drug reactions, was queried for drug hypersensitivity reactions using the key terms: hypersensitivity, allergic reaction, allergy, anaphylaxis, allergic dermatitis, and drug hypersensitivity. Results Preliminary population analysis of 425 of the 1605 qualifying clinical trials from this dataset revealed 3,013 adverse drug hypersensitivity reactions of 118,159 patients at risk for HSRs (2.5% incidence).",

keywords = "Cancer, Clinical trials, Data management, Data processing, Data analysis, Anaphylaxis, Studies, Hypersensitivity",

author = "Christina Eldredge and Arun Singavi and Cesar Lam and Joel Gallagher and Jake Luo",

year = "2018",

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doi = "10.1016/j.jaci.2017.12.279",

language = "American English",

note = "Journal of Allergy and Clinical Immunology ; Conference date: 01-03-2018",

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TY - CONF

T1 - Big Data Analysis of Drug Induced Hypersensitivity and Anaphylaxis Reactions in Clinical Cancer Trials

AU - Eldredge, Christina

AU - Singavi, Arun

AU - Lam, Cesar

AU - Gallagher, Joel

AU - Luo, Jake

PY - 2018/3/1

Y1 - 2018/3/1

N2 - The dataset, which included study name, medical condition, intervention, arm titles, and adverse drug reactions, was queried for drug hypersensitivity reactions using the key terms: hypersensitivity, allergic reaction, allergy, anaphylaxis, allergic dermatitis, and drug hypersensitivity. Results Preliminary population analysis of 425 of the 1605 qualifying clinical trials from this dataset revealed 3,013 adverse drug hypersensitivity reactions of 118,159 patients at risk for HSRs (2.5% incidence).

AB - The dataset, which included study name, medical condition, intervention, arm titles, and adverse drug reactions, was queried for drug hypersensitivity reactions using the key terms: hypersensitivity, allergic reaction, allergy, anaphylaxis, allergic dermatitis, and drug hypersensitivity. Results Preliminary population analysis of 425 of the 1605 qualifying clinical trials from this dataset revealed 3,013 adverse drug hypersensitivity reactions of 118,159 patients at risk for HSRs (2.5% incidence).

KW - Cancer

KW - Clinical trials

KW - Data management

KW - Data processing

KW - Data analysis

KW - Anaphylaxis

KW - Studies

KW - Hypersensitivity

UR - https://digitalcommons.usf.edu/si_facpub/446

UR - https://doi.org/10.1016/j.jaci.2017.12.279

U2 - 10.1016/j.jaci.2017.12.279

DO - 10.1016/j.jaci.2017.12.279

M3 - Presentation

T2 - Journal of Allergy and Clinical Immunology

Y2 - 1 March 2018

ER -

Big Data Analysis of Drug Induced Hypersensitivity and Anaphylaxis Reactions in Clinical Cancer Trials

Abstract

Conference

Keywords

Disciplines

Access to Document

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