TY - JOUR
T1 - Chest Radiograph Screening for Detecting Subclinical Tuberculosis in Asymptomatic Household Contacts, Peru
AU - Tan, Qi
AU - Huang, Chuan-Chin
AU - Becerra, Mercedes C.
AU - Calderon, Roger
AU - Contreras, Carmen
AU - Lecca, Leonid
AU - Jimenez, Judith
AU - Yataco, Rosa
AU - Galea, Jerome
AU - Feng, Jia-Yih
AU - Pan, Sheng-Wei
AU - Tseng, Yen-Han
AU - Huang, Jhong-Ru
AU - Zhang, Zibiao
AU - Murray, Megan B.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - The World Health Organization’s end TB strategy promotes the use of symptom and chest radiograph screening for tuberculosis (TB) disease. However, asymptomatic early states of TB beyond latent TB infection and active disease can go unrecognized using current screening criteria. We conducted a longitudinal cohort study enrolling household contacts initially free of TB disease and followed them for the occurrence of incident TB over 1 year. Among 1,747 screened contacts, 27 (52%) of the 52 persons in whom TB subsequently developed during follow-up had a baseline abnormal radiograph. Of contacts without TB symptoms, persons with an abnormal radiograph were at higher risk for subsequent TB than persons with an unremarkable radiograph (adjusted hazard ratio 15.62 [95% CI 7.74–31.54]). In young adults, we found a strong linear relationship between radiograph severity and time to TB diagnosis. Our findings suggest chest radiograph screening can extend to detecting early TB states, thereby enabling timely intervention.
AB - The World Health Organization’s end TB strategy promotes the use of symptom and chest radiograph screening for tuberculosis (TB) disease. However, asymptomatic early states of TB beyond latent TB infection and active disease can go unrecognized using current screening criteria. We conducted a longitudinal cohort study enrolling household contacts initially free of TB disease and followed them for the occurrence of incident TB over 1 year. Among 1,747 screened contacts, 27 (52%) of the 52 persons in whom TB subsequently developed during follow-up had a baseline abnormal radiograph. Of contacts without TB symptoms, persons with an abnormal radiograph were at higher risk for subsequent TB than persons with an unremarkable radiograph (adjusted hazard ratio 15.62 [95% CI 7.74–31.54]). In young adults, we found a strong linear relationship between radiograph severity and time to TB diagnosis. Our findings suggest chest radiograph screening can extend to detecting early TB states, thereby enabling timely intervention.
U2 - 10.3201/eid3006.231699
DO - 10.3201/eid3006.231699
M3 - Article
VL - 30
SP - 1115
EP - 1124
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 6
ER -