Extracellular Matrix Biomarkers of Adverse Remodeling after Myocardial Infarction

Kristine Y. DeLeon; Lisandra E.de Brás; Yonggang Ma; Ganesh V. Halade; Jianhua Zhang; Merry L. Lindsey

doi:10.1007/978-1-4614-5930-9_22

Extracellular Matrix Biomarkers of Adverse Remodeling after Myocardial Infarction

Kristine Y. DeLeon, Lisandra E.de Brás, Yonggang Ma, Ganesh V. Halade, Jianhua Zhang, Merry L. Lindsey

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Approximately every minute, someone will die from a myocardial infarction (MI). A MI is the result of an obstruction of blood supply causing the heart to undergo complex structural and functional changes in the left ventricular wall, known as ventricular remodeling. Cardiomyocytes undergo necrosis rapidly after the onset of injury, leading to early accumulation of neutrophils, activation of metalloproteinases, and degradation of the stromal tissue, eventually leading to formation of a collagen scar. Circulating factors related to inflammatory and fibrotic responses are key predictors of extracellular matrix (ECM) changes that occur after MI. Changes in the collagen network of the ECM can alter myocardial stiffness, consequently leading to cardiac hypertrophy, fibrosis, and LV dysfunction. Proteins and peptides of the ECM are promising biomarkers for MI. This book chapter provides an overview of key ECM biomarkers involved in adverse remodeling post-MI and their practical applications.

Original language	American English
Title of host publication	Cardiac Remodeling. Advances in Biochemistry in Health and Disease
DOIs	https://doi.org/10.1007/978-1-4614-5930-9_22
State	Published - Jan 1 2013
Externally published	Yes

Keywords

Biomarkers
Cardiac remodeling
Extracellular matrix
Myocardial infarction

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10.1007/978-1-4614-5930-9_22License: CC BY

https://doi.org/10.1007/978-1-4614-5930-9_22

Cite this

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abstract = " Approximately every minute, someone will die from a myocardial infarction (MI). A MI is the result of an obstruction of blood supply causing the heart to undergo complex structural and functional changes in the left ventricular wall, known as ventricular remodeling. Cardiomyocytes undergo necrosis rapidly after the onset of injury, leading to early accumulation of neutrophils, activation of metalloproteinases, and degradation of the stromal tissue, eventually leading to formation of a collagen scar. Circulating factors related to inflammatory and fibrotic responses are key predictors of extracellular matrix (ECM) changes that occur after MI. Changes in the collagen network of the ECM can alter myocardial stiffness, consequently leading to cardiac hypertrophy, fibrosis, and LV dysfunction. Proteins and peptides of the ECM are promising biomarkers for MI. This book chapter provides an overview of key ECM biomarkers involved in adverse remodeling post-MI and their practical applications.",

keywords = "Biomarkers, Cardiac remodeling, Extracellular matrix, Myocardial infarction",

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AU - DeLeon, Kristine Y.

AU - Brás, Lisandra E.de

AU - Ma, Yonggang

AU - Halade, Ganesh V.

AU - Zhang, Jianhua

AU - Lindsey, Merry L.

PY - 2013/1/1

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N2 - Approximately every minute, someone will die from a myocardial infarction (MI). A MI is the result of an obstruction of blood supply causing the heart to undergo complex structural and functional changes in the left ventricular wall, known as ventricular remodeling. Cardiomyocytes undergo necrosis rapidly after the onset of injury, leading to early accumulation of neutrophils, activation of metalloproteinases, and degradation of the stromal tissue, eventually leading to formation of a collagen scar. Circulating factors related to inflammatory and fibrotic responses are key predictors of extracellular matrix (ECM) changes that occur after MI. Changes in the collagen network of the ECM can alter myocardial stiffness, consequently leading to cardiac hypertrophy, fibrosis, and LV dysfunction. Proteins and peptides of the ECM are promising biomarkers for MI. This book chapter provides an overview of key ECM biomarkers involved in adverse remodeling post-MI and their practical applications.

AB - Approximately every minute, someone will die from a myocardial infarction (MI). A MI is the result of an obstruction of blood supply causing the heart to undergo complex structural and functional changes in the left ventricular wall, known as ventricular remodeling. Cardiomyocytes undergo necrosis rapidly after the onset of injury, leading to early accumulation of neutrophils, activation of metalloproteinases, and degradation of the stromal tissue, eventually leading to formation of a collagen scar. Circulating factors related to inflammatory and fibrotic responses are key predictors of extracellular matrix (ECM) changes that occur after MI. Changes in the collagen network of the ECM can alter myocardial stiffness, consequently leading to cardiac hypertrophy, fibrosis, and LV dysfunction. Proteins and peptides of the ECM are promising biomarkers for MI. This book chapter provides an overview of key ECM biomarkers involved in adverse remodeling post-MI and their practical applications.

KW - Biomarkers

KW - Cardiac remodeling

KW - Extracellular matrix

KW - Myocardial infarction

UR - https://digitalcommons.usf.edu/intmed_facpub/58

UR - https://doi.org/10.1007/978-1-4614-5930-9_22

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M3 - Chapter

BT - Cardiac Remodeling. Advances in Biochemistry in Health and Disease

ER -

Extracellular Matrix Biomarkers of Adverse Remodeling after Myocardial Infarction

Abstract

Keywords

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