Hearing Treatment for Reducing Cognitive Decline: Design and Methods of the Aging and Cognitive Health Evaluation in Elders Randomized Controlled Trial

Jennifer A. Deal; Adele M. Goman; Marilyn S. Albert; Michelle L. Arnold; Sheila Burgard; Theresa Chisolm; David Couper; Nancy W. Glynn; Theresa Gmelin; Kathleen M. Hayden; Thomas Mosley; James S. Pankow; Nicholas Reed; Victoria Sanchez; A. Richey Sharrett; Sonia D. Thomas; Josef Coresh; Frank R. Lin

doi:10.1016/j.trci.2018.08.007

Hearing Treatment for Reducing Cognitive Decline: Design and Methods of the Aging and Cognitive Health Evaluation in Elders Randomized Controlled Trial

Jennifer A. Deal
, Adele M. Goman
, Marilyn S. Albert
, Michelle L. Arnold
, Sheila Burgard
, Theresa Chisolm
, David Couper
, Nancy W. Glynn
, Theresa Gmelin
, Kathleen M. Hayden
, Thomas Mosley
, James S. Pankow
, Nicholas Reed
, Victoria Sanchez
, A. Richey Sharrett
, Sonia D. Thomas
, Josef Coresh
, Frank R. Lin

University of South Florida

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Hearing impairment is highly prevalent and independently associated with cognitive decline. The Aging and Cognitive Health Evaluation in Elders study is a multicenter randomized controlled trial to determine efficacy of hearing treatment in reducing cognitive decline in older adults. Clinicaltrials.gov Identifier: NCT03243422 .

Methods: Eight hundred fifty participants without dementia aged 70 to 84 years with mild-to-moderate hearing impairment recruited from four United States field sites and randomized 1:1 to a best-practices hearing intervention or health education control. Primary study outcome is 3-year change in global cognitive function. Secondary outcomes include domain-specific cognitive decline, incident dementia, brain structural changes on magnetic resonance imaging, health-related quality of life, physical and social function, and physical activity.

Results: Trial enrollment began January 4, 2018 and is ongoing.

Discussion: When completed in 2022, Aging and Cognitive Health Evaluation in Elders study should provide definitive evidence of the effect of hearing treatment versus education control on cognitive decline in community-dwelling older adults with mild-to-moderate hearing impairment.

Original language	American English
Journal	Alzheimer's & Dementia: Translational Research & Clinical Interventions
Volume	4
DOIs	https://doi.org/10.1016/j.trci.2018.08.007
State	Published - Jan 1 2018

Keywords

Clinical trials
Cognition
Dementia
Epidemiology
Hearing
Longitudinal study
Memory
Presbycusis

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Deal, J. A., Goman, A. M., Albert, M. S., Arnold, M. L., Burgard, S., Chisolm, T., Couper, D., Glynn, N. W., Gmelin, T., Hayden, K. M., Mosley, T., Pankow, J. S., Reed, N., Sanchez, V., Sharrett, A. R., Thomas, S. D., Coresh, J., & Lin, F. R. (2018). Hearing Treatment for Reducing Cognitive Decline: Design and Methods of the Aging and Cognitive Health Evaluation in Elders Randomized Controlled Trial. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 4. https://doi.org/10.1016/j.trci.2018.08.007

Hearing Treatment for Reducing Cognitive Decline: Design and Methods of the Aging and Cognitive Health Evaluation in Elders Randomized Controlled Trial. / Deal, Jennifer A.; Goman, Adele M.; Albert, Marilyn S. et al.
In: Alzheimer's & Dementia: Translational Research & Clinical Interventions, Vol. 4, 01.01.2018.

Research output: Contribution to journal › Article › peer-review

Deal, JA, Goman, AM, Albert, MS, Arnold, ML, Burgard, S, Chisolm, T, Couper, D, Glynn, NW, Gmelin, T, Hayden, KM, Mosley, T, Pankow, JS, Reed, N, Sanchez, V, Sharrett, AR, Thomas, SD, Coresh, J & Lin, FR 2018, 'Hearing Treatment for Reducing Cognitive Decline: Design and Methods of the Aging and Cognitive Health Evaluation in Elders Randomized Controlled Trial', Alzheimer's & Dementia: Translational Research & Clinical Interventions, vol. 4. https://doi.org/10.1016/j.trci.2018.08.007

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title = "Hearing Treatment for Reducing Cognitive Decline: Design and Methods of the Aging and Cognitive Health Evaluation in Elders Randomized Controlled Trial",

abstract = " Introduction: Hearing impairment is highly prevalent and independently associated with cognitive decline. The Aging and Cognitive Health Evaluation in Elders study is a multicenter randomized controlled trial to determine efficacy of hearing treatment in reducing cognitive decline in older adults. Clinicaltrials.gov Identifier: NCT03243422 . Methods: Eight hundred fifty participants without dementia aged 70 to 84 years with mild-to-moderate hearing impairment recruited from four United States field sites and randomized 1:1 to a best-practices hearing intervention or health education control. Primary study outcome is 3-year change in global cognitive function. Secondary outcomes include domain-specific cognitive decline, incident dementia, brain structural changes on magnetic resonance imaging, health-related quality of life, physical and social function, and physical activity. Results: Trial enrollment began January 4, 2018 and is ongoing. Discussion: When completed in 2022, Aging and Cognitive Health Evaluation in Elders study should provide definitive evidence of the effect of hearing treatment versus education control on cognitive decline in community-dwelling older adults with mild-to-moderate hearing impairment.",

keywords = "Clinical trials, Cognition, Dementia, Epidemiology, Hearing, Longitudinal study, Memory, Presbycusis",

author = "Deal, \{Jennifer A.\} and Goman, \{Adele M.\} and Albert, \{Marilyn S.\} and Arnold, \{Michelle L.\} and Sheila Burgard and Theresa Chisolm and David Couper and Glynn, \{Nancy W.\} and Theresa Gmelin and Hayden, \{Kathleen M.\} and Thomas Mosley and Pankow, \{James S.\} and Nicholas Reed and Victoria Sanchez and Sharrett, \{A. Richey\} and Thomas, \{Sonia D.\} and Josef Coresh and Lin, \{Frank R.\}",

year = "2018",

month = jan,

day = "1",

doi = "10.1016/j.trci.2018.08.007",

language = "American English",

volume = "4",

journal = "Alzheimer's \& Dementia: Translational Research \& Clinical Interventions",

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T1 - Hearing Treatment for Reducing Cognitive Decline: Design and Methods of the Aging and Cognitive Health Evaluation in Elders Randomized Controlled Trial

AU - Deal, Jennifer A.

AU - Goman, Adele M.

AU - Albert, Marilyn S.

AU - Arnold, Michelle L.

AU - Burgard, Sheila

AU - Chisolm, Theresa

AU - Couper, David

AU - Glynn, Nancy W.

AU - Gmelin, Theresa

AU - Hayden, Kathleen M.

AU - Mosley, Thomas

AU - Pankow, James S.

AU - Reed, Nicholas

AU - Sanchez, Victoria

AU - Sharrett, A. Richey

AU - Thomas, Sonia D.

AU - Coresh, Josef

AU - Lin, Frank R.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Introduction: Hearing impairment is highly prevalent and independently associated with cognitive decline. The Aging and Cognitive Health Evaluation in Elders study is a multicenter randomized controlled trial to determine efficacy of hearing treatment in reducing cognitive decline in older adults. Clinicaltrials.gov Identifier: NCT03243422 . Methods: Eight hundred fifty participants without dementia aged 70 to 84 years with mild-to-moderate hearing impairment recruited from four United States field sites and randomized 1:1 to a best-practices hearing intervention or health education control. Primary study outcome is 3-year change in global cognitive function. Secondary outcomes include domain-specific cognitive decline, incident dementia, brain structural changes on magnetic resonance imaging, health-related quality of life, physical and social function, and physical activity. Results: Trial enrollment began January 4, 2018 and is ongoing. Discussion: When completed in 2022, Aging and Cognitive Health Evaluation in Elders study should provide definitive evidence of the effect of hearing treatment versus education control on cognitive decline in community-dwelling older adults with mild-to-moderate hearing impairment.

AB - Introduction: Hearing impairment is highly prevalent and independently associated with cognitive decline. The Aging and Cognitive Health Evaluation in Elders study is a multicenter randomized controlled trial to determine efficacy of hearing treatment in reducing cognitive decline in older adults. Clinicaltrials.gov Identifier: NCT03243422 . Methods: Eight hundred fifty participants without dementia aged 70 to 84 years with mild-to-moderate hearing impairment recruited from four United States field sites and randomized 1:1 to a best-practices hearing intervention or health education control. Primary study outcome is 3-year change in global cognitive function. Secondary outcomes include domain-specific cognitive decline, incident dementia, brain structural changes on magnetic resonance imaging, health-related quality of life, physical and social function, and physical activity. Results: Trial enrollment began January 4, 2018 and is ongoing. Discussion: When completed in 2022, Aging and Cognitive Health Evaluation in Elders study should provide definitive evidence of the effect of hearing treatment versus education control on cognitive decline in community-dwelling older adults with mild-to-moderate hearing impairment.

KW - Clinical trials

KW - Cognition

KW - Dementia

KW - Epidemiology

KW - Hearing

KW - Longitudinal study

KW - Memory

KW - Presbycusis

UR - https://digitalcommons.usf.edu/csd_facpub_sm/14

U2 - 10.1016/j.trci.2018.08.007

DO - 10.1016/j.trci.2018.08.007

M3 - Article

C2 - 30364572

VL - 4

JO - Alzheimer's & Dementia: Translational Research & Clinical Interventions

JF - Alzheimer's & Dementia: Translational Research & Clinical Interventions

ER -

Hearing Treatment for Reducing Cognitive Decline: Design and Methods of the Aging and Cognitive Health Evaluation in Elders Randomized Controlled Trial

Abstract

Keywords

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