Liver tests in dogs receiving anticonvulsant drugs (diphenylhydantoin and primidone).

David J. Meyer; Norine E. Noonan

Liver tests in dogs receiving anticonvulsant drugs (diphenylhydantoin and primidone).

University of South Florida

Research output: Contribution to journal › Article › peer-review

Abstract

Two groups of adult female dogs were given diphenylhydantoin or primidone orally for 82 days. Plasma glutamic-pyruvic transaminase (GPT), alkaline phosphatase (AP) and gamma-glutamyl transferase (GGT) activity, total plasma bilirubin (TBR) concentration, fasting bile acid level and percent sulfobromophthalein (% BSP) retention were determined in the dogs prior to and after treatment. Plasma GPT and AP showed persistent increases in some dogs, while occasional increases occurred in the remaining dogs in both groups. The plasma enzymes returned to normal 5 wk after treatment. Plasma GGT, TBR, fasting bile acids and % BSP retention were normal during the study.

Original language	American English
Journal	Default journal
State	Published - Jan 1 1981

Keywords

Blood and lymphatics
Digestive system
Enzymology
Nervous system
Pharmacology
Toxicology

Disciplines

Biology

Cite this

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title = "Liver tests in dogs receiving anticonvulsant drugs (diphenylhydantoin and primidone).",

abstract = " Two groups of adult female dogs were given diphenylhydantoin or primidone orally for 82 days. Plasma glutamic-pyruvic transaminase (GPT), alkaline phosphatase (AP) and gamma-glutamyl transferase (GGT) activity, total plasma bilirubin (TBR) concentration, fasting bile acid level and percent sulfobromophthalein (% BSP) retention were determined in the dogs prior to and after treatment. Plasma GPT and AP showed persistent increases in some dogs, while occasional increases occurred in the remaining dogs in both groups. The plasma enzymes returned to normal 5 wk after treatment. Plasma GGT, TBR, fasting bile acids and % BSP retention were normal during the study.",

keywords = "Blood and lymphatics, Digestive system, Enzymology, Nervous system, Pharmacology, Toxicology",

author = "Meyer, {David J.} and Noonan, {Norine E.}",

note = "Meyer, D.J., & Noonan, N.E. (1981). Liver tests in dogs receiving anticonvulsant drugs (diphenylhydantoin and primidone). Journal of the American Animal Hospital Association, 17(2), 261-264.",

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T1 - Liver tests in dogs receiving anticonvulsant drugs (diphenylhydantoin and primidone).

AU - Meyer, David J.

AU - Noonan, Norine E.

N1 - Meyer, D.J., & Noonan, N.E. (1981). Liver tests in dogs receiving anticonvulsant drugs (diphenylhydantoin and primidone). Journal of the American Animal Hospital Association, 17(2), 261-264.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - Two groups of adult female dogs were given diphenylhydantoin or primidone orally for 82 days. Plasma glutamic-pyruvic transaminase (GPT), alkaline phosphatase (AP) and gamma-glutamyl transferase (GGT) activity, total plasma bilirubin (TBR) concentration, fasting bile acid level and percent sulfobromophthalein (% BSP) retention were determined in the dogs prior to and after treatment. Plasma GPT and AP showed persistent increases in some dogs, while occasional increases occurred in the remaining dogs in both groups. The plasma enzymes returned to normal 5 wk after treatment. Plasma GGT, TBR, fasting bile acids and % BSP retention were normal during the study.

AB - Two groups of adult female dogs were given diphenylhydantoin or primidone orally for 82 days. Plasma glutamic-pyruvic transaminase (GPT), alkaline phosphatase (AP) and gamma-glutamyl transferase (GGT) activity, total plasma bilirubin (TBR) concentration, fasting bile acid level and percent sulfobromophthalein (% BSP) retention were determined in the dogs prior to and after treatment. Plasma GPT and AP showed persistent increases in some dogs, while occasional increases occurred in the remaining dogs in both groups. The plasma enzymes returned to normal 5 wk after treatment. Plasma GGT, TBR, fasting bile acids and % BSP retention were normal during the study.

KW - Blood and lymphatics

KW - Digestive system

KW - Enzymology

KW - Nervous system

KW - Pharmacology

KW - Toxicology

UR - https://digitalcommons.usf.edu/fac_publications/1893

M3 - Article

JO - Default journal

JF - Default journal

ER -

Liver tests in dogs receiving anticonvulsant drugs (diphenylhydantoin and primidone).

Abstract

Keywords

Disciplines

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