TY - JOUR
T1 - Mathematical Modeling of Macrophage Activation in Left Ventricular Remodeling Post-Myocardial Infarction
AU - Wang, Yunji
AU - Jin, Yufang
AU - Ma, Yonggang
AU - Halade, Ganesh V.
AU - Linsey, Merry L.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - The macrophage plays a key role in regulating the remodeling of the left ventricle (LV) post-myocardial infarction (MI). However, the underlying regulatory mechanisms of macrophage activations were understudied. The goal of this study, therefore, was to establish a framework for macrophage activations and build a mathematical model based on the framework by integrating computational and experimental approaches. Accordingly, we established a framework including myocytes, monocytes, macrophages, and interlukin-1 (IL-1), IL-10, and tumor necrosis-alpha (TNF-α) based on literature, established a set of ordinary differential equations as the mathematical model, and primarily validated the model with experimental results. This study provides a useful tool to further study macrophage activations.
AB - The macrophage plays a key role in regulating the remodeling of the left ventricle (LV) post-myocardial infarction (MI). However, the underlying regulatory mechanisms of macrophage activations were understudied. The goal of this study, therefore, was to establish a framework for macrophage activations and build a mathematical model based on the framework by integrating computational and experimental approaches. Accordingly, we established a framework including myocytes, monocytes, macrophages, and interlukin-1 (IL-1), IL-10, and tumor necrosis-alpha (TNF-α) based on literature, established a set of ordinary differential equations as the mathematical model, and primarily validated the model with experimental results. This study provides a useful tool to further study macrophage activations.
UR - https://digitalcommons.usf.edu/intmed_facpub/72
UR - https://doi.org/10.1109/gensips.2011.6169480
U2 - 10.1109/gensips.2011.6169480
DO - 10.1109/gensips.2011.6169480
M3 - Article
JO - 2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)
JF - 2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)
ER -