TY - CHAP
T1 - Microviridae
AU - Breitbart, Mya
AU - Fane, Bentley A.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Members of the Microviridae comprise at least two subfamilies ( Bullavirinae and Gokushovirinae ), with divergent sequences from many uncultured representatives yet to be formally classified. Bullaviruses (canonical species φX174), which infect free-living bacteria, are among the fastest known replicating viruses. Gokushoviruses were originally thought to occupy a unique niche, infecting obligate intracellular bacteria; however, genomic analyses suggest that this group infects free-living hosts as well. Some gokushoviruses, unlike other members of the family, can undergo both lytic and lysogenic replication cycles. Microviridae contain small (4000–6000 bases), circular and single-stranded deoxyribonucleic acid (ssDNA) genomes of positive polarity, which are packaged inside small (∼25 nm diameter) T = 1 icosahedral capsids. The most well-known member of the Microviridae , φX174, has been fundamental in uncovering the mechanisms of DNA replication and capsid assembly and become a model system for experimental evolution. In contrast, little is known about the replication, structure and host range of gokushoviruses despite viromics indicating their ubiquity throughout the biosphere.
AB - Members of the Microviridae comprise at least two subfamilies ( Bullavirinae and Gokushovirinae ), with divergent sequences from many uncultured representatives yet to be formally classified. Bullaviruses (canonical species φX174), which infect free-living bacteria, are among the fastest known replicating viruses. Gokushoviruses were originally thought to occupy a unique niche, infecting obligate intracellular bacteria; however, genomic analyses suggest that this group infects free-living hosts as well. Some gokushoviruses, unlike other members of the family, can undergo both lytic and lysogenic replication cycles. Microviridae contain small (4000–6000 bases), circular and single-stranded deoxyribonucleic acid (ssDNA) genomes of positive polarity, which are packaged inside small (∼25 nm diameter) T = 1 icosahedral capsids. The most well-known member of the Microviridae , φX174, has been fundamental in uncovering the mechanisms of DNA replication and capsid assembly and become a model system for experimental evolution. In contrast, little is known about the replication, structure and host range of gokushoviruses despite viromics indicating their ubiquity throughout the biosphere.
UR - https://digitalcommons.usf.edu/msc_facpub/1360
UR - https://doi.org/10.1002/9780470015902.a0029280
U2 - 10.1002/9780470015902.a0029280
DO - 10.1002/9780470015902.a0029280
M3 - Chapter
BT - eLS
ER -