New animal-model with hyper-bilitrubinemia: The indigo snake.

Norine E. Noonan, Gerald A. Olsen, Charles E. Cornelius

Research output: Contribution to journalArticlepeer-review

Abstract

An unconjugated hyper-bilirubinemia has been observed in all species of normal indigo snakes. The plasma clearance of large organic anions such as sulfobromophthalein and unconjugated bilirubin was markedly delayed when compared to other snake species. Endogenous bile flow and biliverdin and bilirubin excretory rates and the excretion of bile pigments after a bilirubin load were measured in various snakes. The indigo snake represents a new animal model in which to study mechanisms important to hepatic anion uptake and biliary transport.

Original languageAmerican English
JournalDefault journal
StatePublished - Jan 1 1979

Keywords

  • Animals
  • Bile
  • Bilirubin
  • Disease models
  • Humans
  • Species specificity
  • Snakes
  • Hyper-bilitrubinemia

Disciplines

  • Biology

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