TY - JOUR
T1 - Novel Anellovirus Discovered From a Mortality Event of Captive California Sea Lions
AU - Ng, Terry Fei Fan
AU - Suedmeyer, Wm Kirk
AU - Wheeler, Elizabeth
AU - Gulland, Frances
AU - Breitbart, Mya
PY - 2009/1/1
Y1 - 2009/1/1
N2 - A viral metagenomic study was performed to investigate potential viral pathogens associated with a mortality event of three captive California sea lions (Zalophus californianus). This study identified a novel California sea lion anellovirus (ZcAV), with 35 % amino acid identity in the ORF1 region to feline anelloviruses. The double-stranded replicative form of ZcAV was detected in lung tissue, suggesting that ZcAV replicates in sea lion lungs. Specific PCR revealed the presence of ZcAV in the lung tissue of all three sea lions involved in the mortality event, but not in three other sea lions from the same zoo. In addition, ZcAV was detected at low frequency (11 %) in the lungs of wild sea lions. The higher prevalence of ZcAV and presence of the double-stranded replicative form in the lungs of sea lions from the mortality event suggest that ZcAV was associated with the death of these animals.
AB - A viral metagenomic study was performed to investigate potential viral pathogens associated with a mortality event of three captive California sea lions (Zalophus californianus). This study identified a novel California sea lion anellovirus (ZcAV), with 35 % amino acid identity in the ORF1 region to feline anelloviruses. The double-stranded replicative form of ZcAV was detected in lung tissue, suggesting that ZcAV replicates in sea lion lungs. Specific PCR revealed the presence of ZcAV in the lung tissue of all three sea lions involved in the mortality event, but not in three other sea lions from the same zoo. In addition, ZcAV was detected at low frequency (11 %) in the lungs of wild sea lions. The higher prevalence of ZcAV and presence of the double-stranded replicative form in the lungs of sea lions from the mortality event suggest that ZcAV was associated with the death of these animals.
UR - https://digitalcommons.usf.edu/msc_facpub/767
UR - https://doi.org/10.1099/vir.0.008987-0
U2 - 10.1099/vir.0.008987-0
DO - 10.1099/vir.0.008987-0
M3 - Article
C2 - 19264590
VL - 90
JO - Journal of General Virology
JF - Journal of General Virology
ER -