Obesity and Cardiometabolic Defects in Heart Failure Pathology

Ganesh V. Halade, Vasundhara Kain

Research output: Contribution to journalArticlepeer-review

Abstract

Obesity is a major global epidemic that sets the stage for diverse multiple pathologies, including cardiovascular disease. The obesity-related low-grade chronic inflamed milieu is more pronounced in aging and responsive to cardiac dysfunction in heart failure pathology. Metabolic dysregulation of obesity integrates with immune reservoir in spleen and kidney network. Therefore, an integrative systems biology approach is necessary to delay progressive cardiac alternations. The purpose of this comprehensive review is to largely discuss the impact of obesity on the cardiovascular pathobiology in the context of problems and challenges, with major emphasis on the diversified models, and to study cardiac remodeling in obesity. The information in this article is immensely helpful in teaching advanced undergraduate, graduate, and medical students about the advancement and impact of obesity on cardiovascular health.

Original languageAmerican English
JournalComprehensive Physiology
Volume7
DOIs
StatePublished - Oct 1 2017
Externally publishedYes

Cite this