Salt loading decreases intraday cardiac variability in dogs

David A. Anderson, Michael Sharinus, William D. Kearns

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Several recent studies have shown that the acute cardiovascular response to behavioral stress or to adrenergic stimulation is increased in salt-loaded humans and laboratory animals. The present study examined the 24-hour variability of heart rate of laboratory dogs under conditions of significant increased in intraarterial intake of isotonic saline. These data are consistent with the hypothesis that increased sodium intake is associated with decreased chronotropic responsivity to intermittent chanaes in autonomic nervous system activity, conceivably due to a sodium-induced "down regulation" of beta-adrenergic receptors.

Original languageAmerican English
Title of host publicationStress, reactivity and cardiovascular disease: Proceedings of the working conference
StatePublished - 1984

Keywords

  • hypertension
  • behavioral stress

Disciplines

  • Medicine and Health Sciences
  • Psychology
  • Social and Behavioral Sciences

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