Viral Diversity and Dynamics in an Infant Gut

Mya Breitbart; Matthew Haynes; Scott Kelley; Florent Angly; Robert Edwards; Ben Felts; Joseph Mahaffy; Jennifer Mueller; James Nulton; Steve Rayhawk; Beltran Rodriguez-Brito; Peter Salamon; Forest Rohwer

doi:10.1016/j.resmic.2008.04.006

Viral Diversity and Dynamics in an Infant Gut

Mya Breitbart, Matthew Haynes, Scott Kelley, Florent Angly, Robert Edwards, Ben Felts, Joseph Mahaffy, Jennifer Mueller, James Nulton, Steve Rayhawk, Beltran Rodriguez-Brito, Peter Salamon, Forest Rohwer

College of Marine Science

Research output: Contribution to journal › Article › peer-review

Abstract

Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.

Original language	American English
Journal	Research in Microbiology
Volume	159
DOIs	https://doi.org/10.1016/j.resmic.2008.04.006
State	Published - Jan 1 2008

Keywords

Infant
Feces
Virus
Phage
Metagenomics
Microarray
Gut

Disciplines

Life Sciences

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10.1016/j.resmic.2008.04.006License: CC BY

https://doi.org/10.1016/j.resmic.2008.04.006

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title = "Viral Diversity and Dynamics in an Infant Gut",

abstract = " Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.",

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T1 - Viral Diversity and Dynamics in an Infant Gut

AU - Breitbart, Mya

AU - Haynes, Matthew

AU - Kelley, Scott

AU - Angly, Florent

AU - Edwards, Robert

AU - Felts, Ben

AU - Mahaffy, Joseph

AU - Mueller, Jennifer

AU - Nulton, James

AU - Rayhawk, Steve

AU - Rodriguez-Brito, Beltran

AU - Salamon, Peter

AU - Rohwer, Forest

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.

AB - Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.

KW - Infant

KW - Feces

KW - Virus

KW - Phage

KW - Metagenomics

KW - Microarray

KW - Gut

UR - https://digitalcommons.usf.edu/msc_facpub/770

UR - https://doi.org/10.1016/j.resmic.2008.04.006

U2 - 10.1016/j.resmic.2008.04.006

DO - 10.1016/j.resmic.2008.04.006

M3 - Article

C2 - 18541415

VL - 159

JO - Research in Microbiology

JF - Research in Microbiology

ER -

Viral Diversity and Dynamics in an Infant Gut

Abstract

Keywords

Disciplines

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