Viral Diversity and Dynamics in an Infant Gut

Mya Breitbart; Matthew Haynes; Scott Kelley; Florent Angly; Robert Edwards; Ben Felts; Joseph Mahaffy; Jennifer Mueller; James Nulton; Steve Rayhawk; Beltran Rodriguez-Brito; Peter Salamon; Forest Rohwer

doi:10.1016/j.resmic.2008.04.006

Viral Diversity and Dynamics in an Infant Gut

Mya Breitbart
, Matthew Haynes
, Scott Kelley
, Florent Angly
, Robert Edwards
, Ben Felts
, Joseph Mahaffy
, Jennifer Mueller
, James Nulton
, Steve Rayhawk
, Beltran Rodriguez-Brito
, Peter Salamon
, Forest Rohwer

College of Marine Science

Research output: Contribution to journal › Article › peer-review

Abstract

Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.

Original language	American English
Journal	Research in Microbiology
Volume	159
DOIs	https://doi.org/10.1016/j.resmic.2008.04.006
State	Published - Jan 1 2008

Keywords

Infant
Feces
Virus
Phage
Metagenomics
Microarray
Gut

Disciplines

Life Sciences

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10.1016/j.resmic.2008.04.006License: CC BY

https://doi.org/10.1016/j.resmic.2008.04.006

Cite this

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title = "Viral Diversity and Dynamics in an Infant Gut",

abstract = " Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.",

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T1 - Viral Diversity and Dynamics in an Infant Gut

AU - Breitbart, Mya

AU - Haynes, Matthew

AU - Kelley, Scott

AU - Angly, Florent

AU - Edwards, Robert

AU - Felts, Ben

AU - Mahaffy, Joseph

AU - Mueller, Jennifer

AU - Nulton, James

AU - Rayhawk, Steve

AU - Rodriguez-Brito, Beltran

AU - Salamon, Peter

AU - Rohwer, Forest

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.

AB - Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.

KW - Infant

KW - Feces

KW - Virus

KW - Phage

KW - Metagenomics

KW - Microarray

KW - Gut

UR - https://digitalcommons.usf.edu/msc_facpub/770

UR - https://doi.org/10.1016/j.resmic.2008.04.006

U2 - 10.1016/j.resmic.2008.04.006

DO - 10.1016/j.resmic.2008.04.006

M3 - Article

C2 - 18541415

VL - 159

JO - Research in Microbiology

JF - Research in Microbiology

ER -

Viral Diversity and Dynamics in an Infant Gut

Abstract

Keywords

Disciplines

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